![]() We propose that Msn functions together with Bic-D to regulate the apical localization of dynein in generating directed nuclear migration within differentiating R-cell precursor cells. Biochemical studies demonstrate that Msn increases the phosphorylation of Bic-D, which appears to be necessary for the apical accumulation of both Bic-D and dynein in developing R-cell precursor cells. msn displays strong genetic interaction with Bic-D. You are also likely to experience pain when a bright light is shined on the affected eye. Msn, like Bic-D, is required for the apical migration of differentiating R-cell precursor nuclei. The most common symptoms include bloodshot eyes, pain in the eye, headaches, blurred vision and small or misshapen pupils. The definitive diagnosis is made by doing corneal toporgraphy and taking keratometer readings. Here, we show that Misshapen (Msn), the fly homolog of the vertebrate Nck-interacting kinase is a component of a novel signaling pathway that regulates photoreceptor (R-cell) nuclear migration in the developing Drosophila compound eye. Mis shapened cornea could cause: reduced vision, glare, ghost images, sensitivity to light, poor night vision, in some cases red, painful eyes. Nothing is known about the signaling events that coordinate the function of Bic-D and dynein during development. JCH MD Eye Physician & Surgeon (Eye MD Ophthalmologist) Helpful - 0. Bicaudal-D (Bic-D), an evolutionarily conserved dynein-interacting protein, is required for developmental control of nuclear migration in Drosophila. Mis shapened cornea could cause: reduced vision, glare, ghost images, sensitivity to light, poor night vision, in some cases red, painful eyes. Nuclear translocation, driven by the motility apparatus consisting of the cytoplasmic dynein motor and microtubules, is essential for cell migration during embryonic development.
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